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Thyroid stimulating hormone reference range and prevalence of thyroid dysfunction in the Korean population: KNHNES, 2013-2015
- Date2017-09-14 20:40
- Update2017-09-14 20:48
- DivisionDivision of Strategic Planning for Emerging Infectious Diseases
- Tel043-719-7271
Thyroid stimulating hormone reference range and prevalence of thyroid dysfunction in the Korean population: Korea national health and nutrition examination survey, 2013-2015
Woo Gyeong-ji, Kim Hye-jin, Kim Yoon-jung, Oh Kyung-won
Division of Health and Nutrition Survey, Centers for Disease Prevention, KCDC
Kim Won-gu, Kim Won-bae, Kim Tae-yong
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center
Kim Sun-wook, Chung Jae-hoon
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center
Shin Myung-hee
Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine
Park Jin-woo
Department of Surgery, Chungbuk National University College of Medicine
Park Hai-lin
Department of Surgery, CHA Gangnam Medical Center, CHA University, Seoul, Korea
Background: No nationwide epidemiological study evaluating the prevalence of subclinical and overt forms of hypothyroidism and hyperthyroidism has yet been conducted in Korea. This study aimed to evaluate the reference range of serum thyroid stimulating hormone (TSH) and the national prevalence of thyroid dysfunctions in Korea.
Methodology: Nationwide cross-sectional data were analyzed from a representative sample of the civilian, non-institutionalized Korean population (n=6,564) who underwent blood tests for thyroid function and thyroid peroxidase antibody (TPOAb) as part of the Korea National Health and Nutrition Examination Survey (2013-2015).
Results: The reference interval of serum TSH in the Korean reference population was 0.62- 6.86 mIU/L (male 0.63-6.44 mIU/L, females 0.60-7.21 mIU/L). Based on this reference interval, the prevalence of overt and subclinical hypothyroidism was 0.73% (males 0.40%, females 1.10%) and 3.10% (males 2.26%, females 4.04%), respectively. The prevalence of hypothyroidism increased with increasing age until 50-59 years. The prevalence of overt and subclinical hyperthyroidism was 0.54% (males 0.30%, females 0.81%) and 2.98% (males 2.43%, females, 3.59%), respectively.
Conclusion: This study provides important baseline information for understanding the patterns of thyroid dysfunction in Korea.
Woo Gyeong-ji, Kim Hye-jin, Kim Yoon-jung, Oh Kyung-won
Division of Health and Nutrition Survey, Centers for Disease Prevention, KCDC
Kim Won-gu, Kim Won-bae, Kim Tae-yong
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center
Kim Sun-wook, Chung Jae-hoon
Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center
Shin Myung-hee
Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine
Park Jin-woo
Department of Surgery, Chungbuk National University College of Medicine
Park Hai-lin
Department of Surgery, CHA Gangnam Medical Center, CHA University, Seoul, Korea
Background: No nationwide epidemiological study evaluating the prevalence of subclinical and overt forms of hypothyroidism and hyperthyroidism has yet been conducted in Korea. This study aimed to evaluate the reference range of serum thyroid stimulating hormone (TSH) and the national prevalence of thyroid dysfunctions in Korea.
Methodology: Nationwide cross-sectional data were analyzed from a representative sample of the civilian, non-institutionalized Korean population (n=6,564) who underwent blood tests for thyroid function and thyroid peroxidase antibody (TPOAb) as part of the Korea National Health and Nutrition Examination Survey (2013-2015).
Results: The reference interval of serum TSH in the Korean reference population was 0.62- 6.86 mIU/L (male 0.63-6.44 mIU/L, females 0.60-7.21 mIU/L). Based on this reference interval, the prevalence of overt and subclinical hypothyroidism was 0.73% (males 0.40%, females 1.10%) and 3.10% (males 2.26%, females 4.04%), respectively. The prevalence of hypothyroidism increased with increasing age until 50-59 years. The prevalence of overt and subclinical hyperthyroidism was 0.54% (males 0.30%, females 0.81%) and 2.98% (males 2.43%, females, 3.59%), respectively.
Conclusion: This study provides important baseline information for understanding the patterns of thyroid dysfunction in Korea.
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