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Results of laboratory-based enterovirus sentinel surveillance in Korea, 2016
- Date2018-02-14 20:15
- Update2018-02-14 20:15
- DivisionDivision of Strategic Planning for Emerging Infectious Diseases
- Tel043-719-7271
Results of laboratory-based enterovirus sentinel surveillance in Korea, 2016
Yoon Youngsil, Lee Yong-Pyo, Kim Jooae, Choi Wooyoung, Kang Chun
Division of Viral Diseases, Center for Laboratory control of Infectious Diseases, KCDC
Lee June-Woo, Yoo Jung Sik
Division of Vaccine Research, Center for Infectious Diseases Research, KNIH, KCDC
Background: Human enterovirus (HEV) is the main cause of aseptic meningitis, encephalitis, hand, foot and mouth disease (HFMD) and herpangina. In recent years, enterovirus outbreaks have been frequently associated with some serotypes. This study analyzed the genetic characteristics of enterovirus-associated symptomatic cases in Korea in 2016.
Methodology/Results: A total of 2,379 clinical specimens were collected from patients who were suspected of enterovirus infections in 2016. The detection of HEV was performed by real-time reverse tranion polymerase chain reaction (RT-PCR) and nested RT-PCR, while genotype analysis was evaluated based on VP1 gene expression. The overall HEV-positive rate was 37.2% (884/2,379). Of 884 HEV-positive cases, the most frequently presented genotypes were E18 (61.0%), CB5 (7.3%), CA16 (6.2%), and EV71 (5.2%). The detection rate of enterovirus according to symptoms was 42.5% (338/796) for aseptic meningitis, 64.0% (142/222) for HFMD and herpangina, and 42.6% (43/101) for HFMD with complications.
Conclusion: At present, there are no anti-viral treatments specific to HEV infections. This study may encourage studies for the development for HEV vaccines and therapeutics by providing surveillance data of enterovirus infections.
Keywords: Enterovirus, Sentinel surveillance, Aseptic meningitis, Herpangina, Serotypes
Yoon Youngsil, Lee Yong-Pyo, Kim Jooae, Choi Wooyoung, Kang Chun
Division of Viral Diseases, Center for Laboratory control of Infectious Diseases, KCDC
Lee June-Woo, Yoo Jung Sik
Division of Vaccine Research, Center for Infectious Diseases Research, KNIH, KCDC
Background: Human enterovirus (HEV) is the main cause of aseptic meningitis, encephalitis, hand, foot and mouth disease (HFMD) and herpangina. In recent years, enterovirus outbreaks have been frequently associated with some serotypes. This study analyzed the genetic characteristics of enterovirus-associated symptomatic cases in Korea in 2016.
Methodology/Results: A total of 2,379 clinical specimens were collected from patients who were suspected of enterovirus infections in 2016. The detection of HEV was performed by real-time reverse tranion polymerase chain reaction (RT-PCR) and nested RT-PCR, while genotype analysis was evaluated based on VP1 gene expression. The overall HEV-positive rate was 37.2% (884/2,379). Of 884 HEV-positive cases, the most frequently presented genotypes were E18 (61.0%), CB5 (7.3%), CA16 (6.2%), and EV71 (5.2%). The detection rate of enterovirus according to symptoms was 42.5% (338/796) for aseptic meningitis, 64.0% (142/222) for HFMD and herpangina, and 42.6% (43/101) for HFMD with complications.
Conclusion: At present, there are no anti-viral treatments specific to HEV infections. This study may encourage studies for the development for HEV vaccines and therapeutics by providing surveillance data of enterovirus infections.
Keywords: Enterovirus, Sentinel surveillance, Aseptic meningitis, Herpangina, Serotypes
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