Cancers, 2020.12(9), E2705-0, DOI: https://doi.org/10.3390/cancers12092705

Pathway-Based Integrative Analysis of Metabolome and Microbiome Data from Hepatocellular Carcinoma and Liver Cirrhosis Patients

Kim B, Cho E., Yoon JH, Kim S, Cheong J, Cho S, Park T

Abstract

Hepatocellular carcinoma (HCC) is one of the diseases associated with human microbiome. The human microbiome is known to a ect human disease through the metabolites.
The aim of this study was to identify the pathways associated withHCCby integrating microbiome and metabolomic data via a novel pathway-based integrative method named HisCoM-MnM representing Hierarchical structural Component Model for pathway analysis of Microbiome and Metabolome.
Application of HisCoM-MnM to datasets from HCC and liver cirrhosis (LC) patients successfully identified HCC-related pathways related to cancer metabolic reprogramming along with the significant metabolome and metagenome that make up those pathways.

• DOI: https://doi.org/10.3390/cancers12092705
• ISBN or ISSN: 2072-6694

• 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
• This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.