심혈관질환예방관리기술개발

심혈관질환 예방관리를 위한 임상코호트 운영 및 자료연계

• 심혈관질환 고위험군(노인) 코호트 운영(Korea Urban and Rural Elderly Study; KURE)
• 저항성 고혈압 및 특발성 폐동맥 고혈압 코호트 관리 및 운영
• 노인고혈압 임상중재연구 (HOWOLD-BP) 관리 및 운영
• 급성심근경색 환자등록사업 데이터 정제
• 심혈관질환 고위험군(노인) 코호트와 심평원 청구자료 연계 DB구축 및 업데이트

심뇌혈관질환 예방관리 이행지표 개발연구

• 선행질환 고위험군에서 심혈관질환 발생 위험인자 및 위험예측모델 개발
• 심뇌혈관질환 예방관리의 주요요인 및 방해요인 발굴
• 심혈관질환자의 예후관리를 위한 진료지침개발의 근거자료 도출

심뇌혈관질환 이행연구 운영·관리 및 기획 고도화

• 이행연구 운영·관리
• 연구기획의 고도화
• 심뇌혈관질환 연구자문단 운영

심혈관질환 위험요인 발굴 및 기전규명을 통한 질환관리기술 개발

• 심혈관질환의 선행질환 발생 타겟지표 발굴 및 기능연구
• 심혈관질환 관련 유전자 기능 및 조절기전 규명
• 확장형 심근증 등의 진단에 활용되는 유전자 대상 심근세포 기능연구

제브라피쉬 연구시설 운영

• 질환동물모델 구축, 관리 및 질환 관련 유전자 기능 연구
• 제브라피쉬를 활용한 심혈관질환 발생 기전 연구

미세먼지기인 심혈관질환 발생 제어 연구

• 미세먼지기인 심혈관질환 발생 감소 모형 개발 연구
• 심혈관질환자 역학자료 기반 미세먼지기인 심혈관질환 발생 위험예측모델 개발 연구
• 미세먼지에 의한 심혈관질환 발생 기전 및 중재안 마련 연구

논문 목록(2015~2020)

1. Son MK, Park JJ, Lim NK, Kim WH, Choi DJ. Impact of atrial fibrillation in patients with heart failure and reduced, mid-range or preserved ejection fraction. Heart (2020)

2. Lim NK, Park HY, Kim WH, Mancia G, Cho MC. The U-shaped association between achieved blood pressure and risk of cardiovascular events and mortality in elderly and younger patients. Journal of Hypertension (2020)

3. Lee YJ, Kim JY, Lee DY, Park KJ, Kim GH, Kim JE, Roh GS, Lim JY, Koo S, Lim NK, Park HY & Kim WH. Alcohol consumption before pregnancy causes detrimental fetal development and maternal metabolic disorders. Scientific Reports (2020)

4. Kim GY, Lim HJ, Kim WH, Park HY Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. BBRC (2020)

5. Lee SH, Du J, Hwa J and Kim WH. Parkin coordinates platelet stress response in diabetes mellitus:A big role in a small cell. Int. J. Mol. Sci. (2020)

6. Lee SH, Lee S, Du J, Jain K, Ding M, Kadado AJ, Atteya G, Jaji Z, Tyagi T, Kim WH, Herzog RI, Patel A, Ionescu CN, Martin KA & Hwa J. Mitichondrial MsrB2 serves as a switch and transducer for mitophagy. EMBO Mol. Med (2019)

7. Son MK, Lim NK, Park HY. Predicting stroke and death in patients with heart failure using CHA2DS2-VASc score in Asia. BMC Cardiovascular Disorders (2019)

8. Lim NK, Lee SE, Lee HY, et al. Risk prediction for 30-day heart failure-specific readmission or death after discharge: Data from the Korean Acute Heart Failure (KorAHF) registry. Journal of Cardiology (2019)

9. Son MK, Lim NK, Park HY. Trend of prevalence of atrial fibrillation and use of oral anticoagulation therapy in patients with atrial fibrillation in South Korea (2002-2013). Journal of Epidemiology (2018)

10. Lee JW, Lim NK, Park HY. The product of fasting plasma glucose and triglycerides improves risk prediction of type 2 diabetes in middle-aged Koreans. BMC Endocrine Disorders (2018)

11. Son MK, Lim NK, Kim HW, Park HY. Risk of ischemic stroke after atrial fibrillation diagnosis: a national sample cohort. PLoS ONE (2017)

12. Kim GY, Lim HJ, Park HY. Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway. BBRC (2017)

13. Son MK, Lim NK, Cho MC, Park HY. Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002-2010). Korean Circ. J.(2016)

14. Lee JH, Lim NK, Cho MC, Park HY. Epidemiliogy of Heart failure in Korea: Present and Future. Korean Circ. J.(2016)

15. Kim GY, Park JH, Lim HJ, Park HY. Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of endothelial cell. Cell Signal.(2016)

16. Lim NK, Lee JW, Park HY. Validation of the Korean Genome Epidemiliogy Study Risk Score to Predict Incident Hypertension in a Large Nationwide Korean Cohort. Circulation J.(2016)

17. Lee JW, Lim NK, Baek TW, Park SH, Park HY. Anthropometric indices as predictors of hypertension among men and women aged 40–69 years in the Korean population: the Korean Genome and Epidemiliogy Study. BMC Public Health.(2015)

18. Kim GY, Kim H, Lim HJ, Park HY. Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation. Cell Signal.(2015)

19. Kim MJ, Lim NK, Choi SJ, Park HY. Hypertension is an independent risk factor for type 2 diabetes: the Korean genome and epidemiliogy study. Hepertension Res.(2015)

20. Lim NK, Lee JY, Lee JY, Park HY, Cho MC. The Rlie of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiliogy Study. PLOS One.(2015)