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업무분야

국가줄기세포은행 운영

  • (자원관리) 인간줄기세포자원 확보·품질관리·분양·정보제공
  • (국제표준화) 줄기세포은행 운영기반 국제표준기술확보
  • (재생의료연구) 전분화능줄기세포 품질평가, 질병 모델링 연구

인간배아줄기세포주 등록제 운영

  • 인간배아줄기세포주 이용을 위한 등록 심의

GMP 제조시설 운영

  • 임상연구용 줄기세포치료제 생산 지원

추진경과

일자, 주요내용으로 구성된 2008년에서 2018년까지 추진경과 내용
일 자 주요 내용
2008.6 「생명윤리 및 안전에 관한 법률」개정
2010.1 「생명윤리 및 안전에 관한 법률」에 따른 인간배아줄기세포주 등록 사업 개시
2012.7 국립줄기세포재생센터 건립 기본계획 수립
2012.10 질병관리본부내 국가줄기세포은행 개소
2014.3 국립줄기세포재생센터 착공식
2014.10 국가줄기세포은행 자원분양 개시
2016.10 국립줄기세포재생센터 개소식
2017.5 국가줄기세포은행 기탁등록보존기관 지정
2017.12 국립줄기세포재생센터 제조시설 검증 완료
2018.6 임상연구용 세포치료제 시범생산 성공
2018.8 임상연구용 세포치료제 제조지원 품목 선정
2018.10 임상연구용 세포치료제 제조지원 개시

논문목록(2017~)

  • Lee YS et al. Establishment of a human-induced pluripotent stem cell line, KSCBi014-A, from a long QT syndrome type 2 patient harboring a KCNH2 mutation. Stem Cell Res. 2021.
  • Han HJ et al. Generation of a TLR2 knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021.
  • Lee YS et al. Establishment of a human induced pluripotent stem cell line, KSCBi015-A, from a long QT syndrome type 1 patient harboring a KCNQ1 mutation. Stem Cell Res. 2021.
  • Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021.
  • Han HJ et al. Establishment of a TLR3 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021.
  • Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020.
  • Seo HH et al. Modeling Toxoplasma gondii infection in human cerebral organoids. EMI. 2020.
  • Kim BY et al. Generation of induced pluripotent stem cells(KSCBi009-A) from a patient with Prader-Willi syndrome(PWS) featuring deletion of the paternal chromosome region 15q11.2-q13. Stem Cell Res. 2020.
  • Seo HH et al. Generation of a TLR7 heterozygous knockout line (WAe009-A-18) from human embryonic stem cells using CRISPR/Cas9. Stem Cell Res. 2020.
  • Park HY et al. Generation of a human induced pluripotent stem cell line from a patient with Leber congenital amaurosis. Stem Cell Res. 2020.
  • Jo HY et al. Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. Sci Rep. 2020.
  • Yoo DH et al. Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells. BBRC. 2020.
  • Park HY et al. Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells of a Senior-Loken syndrome patient. Stem Cell Res. 2019.
  • Kim BY et al. Generation of patient-specific induced pluripotent stem cells(KSCBi007-A) derived from a patient with Prader-Willi syndrome retain maternal uniparental disomy(UPD). Stem Cell Res. 2019.
  • Lee YS et al. Generation of a PDX1-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-3, using CRISPR/Cas9 system. Stem Cell Res. 2019.
  • Han HW et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Rep. 2019.
  • Kim BY et al. Generation of a patient-specific induced pluripotent stem cell line, KSCBi006-A, for osteogenesis imperfecta type I with the COL1A1, c.3162delT mutation. Stem Cell Res. 2019.
  • Han HJ et al. Generation of a KSCBi005-A-5(TLR8KO-A10) homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019.
  • Lee YS et al. Generation of a NESTIN-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-1, using CRISPR/Cas9 nuclease. Stem Cell Res. 2019.
  • Han HJ et al. Generation of a TLR7 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019.
  • Kim JH et al. A Report from a Workshop of the International Stem Cell Banking Initiative, Held in Collaboration of Global Alliance for iPSC Therapies and the Harvard Stem Cell Institute, Boston, 2017. Stem Cells. 2019.
  • Choi HY et al. Generation of a human induced pluripotent stem cell line, KSCBi003-A, from human adipose tissue-derived mesenchymal stem cells using a chromosomal integration-free system. Stem Cell Res. 2018.
  • Kim BY et al. Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing. BMC Med Genet. 2017.
  • Kim JH et al. Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. Stem Cells Transl Med. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017.
  • Kim BY et al. Optimized detection of insertions/deletions (INDELs) in whole-exome sequencing data. PLoS One. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system. Stem Cell Res. 2017.
  • Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a non-integration system. Stem Cell Res. 2017.
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