목적

• 난치성질환 극복을 위한 줄기세포 연구 및 재생의료 실용화 지원

업무분야

국가줄기세포은행

• 연구용 및 임상용 줄기세포 자원 확보, 배양, 품질관리, 보관 및 분양
• 줄기세포 품질관리를 위한 연구 및 표준화를 위한 국제협력
• 줄기세포 활용 질병 모델링 및 치료제 개발 연구
• 인간 배아줄기세포주 등록

GMP 제조시설

• 임상연구용 세포치료제 제조 지원
• 3차원 바이오프린팅 조직공학치료제 등 차세대 재생의료 치료제 제조기반 구축
• GMP 전문인력 양성

>>> 국가줄기세포은행 분양 줄기세포 목록

>>> GMP 제조시설 현황 및 이용신청절차

추진경과

논문목록(2017~)

• Lee YS et al. Establishment of a human-induced pluripotent stem cell line, KSCBi014-A, from a long QT syndrome type 2 patient harboring a KCNH2 mutation. Stem Cell Res. 2021.
• Han HJ et al. Generation of a TLR2 knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021.
• Lee YS et al. Establishment of a human induced pluripotent stem cell line, KSCBi015-A, from a long QT syndrome type 1 patient harboring a KCNQ1 mutation. Stem Cell Res. 2021.
• Kim JH et al. Korea National Stem Cell Bank. Stem Cell Res. 2021.
• Han HJ et al. Establishment of a TLR3 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2021.
• Jo HY et al. Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation. Sci Rep. 2020.
• Seo HH et al. Modeling Toxoplasma gondii infection in human cerebral organoids. EMI. 2020.
• Kim BY et al. Generation of induced pluripotent stem cells(KSCBi009-A) from a patient with Prader-Willi syndrome(PWS) featuring deletion of the paternal chromosome region 15q11.2-q13. Stem Cell Res. 2020.
• Seo HH et al. Generation of a TLR7 heterozygous knockout line (WAe009-A-18) from human embryonic stem cells using CRISPR/Cas9. Stem Cell Res. 2020.
• Park HY et al. Generation of a human induced pluripotent stem cell line from a patient with Leber congenital amaurosis. Stem Cell Res. 2020.
• Jo HY et al. Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. Sci Rep. 2020.
• Yoo DH et al. Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells. BBRC. 2020.
• Park HY et al. Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells of a Senior-Loken syndrome patient. Stem Cell Res. 2019.
• Kim BY et al. Generation of patient-specific induced pluripotent stem cells(KSCBi007-A) derived from a patient with Prader-Willi syndrome retain maternal uniparental disomy(UPD). Stem Cell Res. 2019.
• Lee YS et al. Generation of a PDX1-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-3, using CRISPR/Cas9 system. Stem Cell Res. 2019.
• Han HW et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Rep. 2019.
• Kim BY et al. Generation of a patient-specific induced pluripotent stem cell line, KSCBi006-A, for osteogenesis imperfecta type I with the COL1A1, c.3162delT mutation. Stem Cell Res. 2019.
• Han HJ et al. Generation of a KSCBi005-A-5(TLR8KO-A10) homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019.
• Lee YS et al. Generation of a NESTIN-EFGP reporter human induced pluripotent stem cell line, KSCBi005-A-1, using CRISPR/Cas9 nuclease. Stem Cell Res. 2019.
• Han HJ et al. Generation of a TLR7 homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2019.
• Kim JH et al. A Report from a Workshop of the International Stem Cell Banking Initiative, Held in Collaboration of Global Alliance for iPSC Therapies and the Harvard Stem Cell Institute, Boston, 2017. Stem Cells. 2019.
• Choi HY et al. Generation of a human induced pluripotent stem cell line, KSCBi003-A, from human adipose tissue-derived mesenchymal stem cells using a chromosomal integration-free system. Stem Cell Res. 2018.
• Kim BY et al. Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing. BMC Med Genet. 2017.
• Kim JH et al. Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells. Stem Cells Transl Med. 2017.
• Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a modified RNA system. Stem Cell Res. 2017.
• Kim BY et al. Optimized detection of insertions/deletions (INDELs) in whole-exome sequencing data. PLoS One. 2017.
• Uhm KO et al. Generation of human induced pluripotent stem cells from urinary cells of a healthy donor using a non-integration system. Stem Cell Res. 2017.
• Uhm KO et al. Generation of human induced pluripotent stem cell lines from human dermal fibroblasts using a non-integration system. Stem Cell Res. 2017.